Influence of the Extraction Solvent and of the Altitude on the Anticancer Activity of Lebanese Eucalyptus camaldulensis Extract Alone or in Combination with Low Dose of Cisplatin in A549 Human Lung Adenocarcinoma Cells

Background: Lung cancer is the second most common worldwide. Eucalyptus plant extract has been shown to have anti-neoplastic effects. We investigated antitumor effect of ethanolic and aqueous extracts camaldulensis collected at different altitudes on A549. In addition, we evaluated additive its combination with low-dose cisplatin (CDDP). Methods: Qualitative quantitative analyses secondary metabolites present in plants were carried out. The antioxidant cytotoxic activities A549 using 2.2-diphenyl-1-picrylhydrazyl radical scavenging activity neutral red assay, respectively. certain concentrations CDDP cells was studied. Results: Ethanoic extract, a higher number active substances observed. four E. showed cells, cytotoxicity for sea-level altitude species. Moreover, dual exposure both low dose Cisplatin an additional concentrations. Conclusions: This study opens novel therapeutic options combinational therapies treatment adenocarcinoma human lungs.